The FBI and ATF have sent agents to assist local authorities, according to Shauna Dunlop with FBI Houston and Franceska Perot with ATF Houston.
A witness told CNN affiliate KPRC that she hid underneath her desk while she heard five or six gunshots at Lone Star College.
One person has been transported to Houston Northwest Medical Center, according to spokeswoman Ashley Walton.
She would not give any further details about the patient.
Footage from KPRC showed a large number of law enforcement personnel on campus, and at least two people being wheeled on gurneys toward ambulances.